Gastric anti-ulcerative and anti-inflammatory activity of metyrosine in rats

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Gastric anti-ulcerative and anti-inflammatory activity of metyrosine in rats.

In this study, the anti-inflammatory and anti-ulcerative effects of metyrosine, a selective tyrosine hydroxylase enzyme inhibitor, were investigated in rats. For ulcer experiments, indomethacin-induced gastric ulcer tests and ethanol-induced gastric ulcer tests were used. For these experiments, rats were fasted for 24 h. Different doses of metyrosine and 25 mg/kg doses of ranitidine were admini...

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Depressive disorders are more common among persons with chronic diseases such as inflammatory bowel disease and anti-inflammatory effect of some antidepressants such as amitriptyline has been reported. Acetic acid colitis was induced in both reserpinised (depressed) and non-reserpinised (normal) rats. Reserpinised groups received reserpine (6 mg/kg, i.p.) one hour prior to colitis induction. Th...

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Anti-inflammatory Effect of Amitriptyline on Ulcerative Colitis in Normal and Reserpine-Induced Depressed Rats

Depressive disorders are more common among persons with chronic diseases such as inflammatory bowel disease and anti-inflammatory effect of some antidepressants such as amitriptyline has been reported. Acetic acid colitis was induced in both reserpinised (depressed) and non-reserpinised (normal) rats. Reserpinised groups received reserpine (6 mg/kg, i.p.) one hour prior to colitis induction. Th...

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Anti-inflammatory Activity in Rats

1. Assistant Professor of Pharmacology, Bahria University Medical & Dental College, Karachi. 2. Assistant Professor of Pharmacology, Bahria University Medical & Dental College, Karachi. 3. Professor of pharmacology, United Medical & Dental College, Karachi 4. Professor of Pharmacology, Bahria University Medical & Dental College, Karachi. ABSTRACT... Objective: To evaluate anti-inflammatory acti...

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ژورنال

عنوان ژورنال: Pharmacological Reports

سال: 2010

ISSN: 1734-1140

DOI: 10.1016/s1734-1140(10)70248-6